It is important to note that long-term use of corticosteroid drugs (usually prescribed for inflammatory discomfort such as skin allergy or arthritis) can result in a rebound effect and excess production of cortisol by the adrenal glands can ensue. The blockade is reversible and appears to be dose-related. They act as a competitive inhibitor of the 3β-hydroxysteroid dehydrogenate enzyme system and thereby inhibit the synthesis of cortisol and aldosterone as well as other steroids. These are a synthetic, orally active steroid analogue. Only your vet is qualified to consult with about this option.ģ-beta-hydroxysteroid-dehydrogenase drugs - These drugs have been shown to be an effective treatment for canine and feline Cushing’s syndrome. Surgery - If your dog's Cushing's disease was caused by a tumor, surgery might be an option. Overall, based on the results of three survival studies, the mean survival time of canines with pituitary-dependent Cushing’s disease, that were treated with this drug, is 24 to 30 months with a total range of 1 day to 13 years. After the first re-evaluation, rechecks should be scheduled every 3-6 months for the rest of the pet’s life to determine whether the dose needs to be adjusted depending on the results of ACTH response testing. Skin and hair coat changes take longer and the progress is variable. Muscle strength and exercise tolerance improve over the first 3-4 weeks. The most obvious and rapid response is a reduction in water intake, urine output, and appetite, which usually occur at the end of the initial course of therapy. Every day, we get calls from customers looking for an alternative to steroid drugs.Īntineoplastic drugs - During its evaluation as an insecticide, a leading antineoplastic drug was discovered to have adrenocorticolytic effects. Corticosteroids sometimes have side effects that are worse than the condition they were used to treat, and make your dog more susceptible to bacterial and viral infections. Note: Your dog's Cushing’s could be caused by a corticosteroid drug - it may be possible to wean your dog off the drug however, this must be performed under professional supervision to avoid complications. If left untreated, Cushing's disease can lead to other conditions like diabetes and heart problems. Cushing's disease can also result from a benign tumor on one of the adrenal glands or the pituitary gland. It is a common side-effect of drugs such as corticosteroids, which are often prescribed to treat canine arthritis, allergies and other ailments. Cushing's disease results from an excess of adrenal gland hormones including cortisol.
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